Poisoning by Cantharidin
نویسندگان
چکیده
منابع مشابه
The Renal Lesion of Experimental Cantharidin Poisoning
Although the study of experimental nephritis by physiological methods shows that the most striking effect of cantharidin is injury of the blood vessels, the great abundance of mitotic figures in the tubular epithelium in the stage of repair points to an equally widespread and severe epithelial injury. Caution must therefore be observed in ascribing the physiological disturbances of kidney funct...
متن کاملAcute kidney injury by cantharidin poisoning following a silly bet on an ugly beetle
Cantharidin is a poisonous substance secreted by blister beetles, including the 'Spanish fly'. Historically, cantharidin was used as an aphrodisiac, vesicant and abortifacient. Symptoms of poisoning include gastrointestinal and genitourinary mucosal irritation along with renal dysfunction. We present the case of a reckless 23-year-old soldier who accepted the challenge of eating a beetle (Berbe...
متن کاملInduction of Suicidal Erythrocyte Death by Cantharidin
The natural phosphoprotein phosphatase inhibitor cantharidin, primarily used for topical treatment of warts, has later been shown to trigger tumor cell apoptosis and is thus considered for the treatment of malignancy. Similar to apoptosis of tumor cells, erythrocytes may undergo eryptosis, a suicidal cell death characterized by cell shrinkage and translocation of cell membrane phosphatidylserin...
متن کاملRadiosensitization of tumour cells by cantharidin and some analogues.
PURPOSE Mammalian cells at mitosis contain chromatin in compacted form and are hypersensitive to ionizing radiation. Previous research had shown some chemicals that induce chromatin compaction within interphase cells act as radiosensitizers. Of these agents, cantharidin (LS-1), which is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), showed good radiosensitizing activity at non-toxi...
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ژورنال
عنوان ژورنال: BMJ
سال: 1954
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.4901.1384